Yes, you can move them.
1. Open the Desktop.
2. Right click on the OneDrive icon in the System Tray and select "Open OneDrive in File Explorer."
3. In the Left column, right click on the OneDrive icon (Should be under the Desktop Icon) and select "Properties."
4. Click on the Location tab. Click on the "Move" button.
5. Scroll until you find where you want the files to go and click Select Folder.
6. When you hit OK or Apply, the files will be moved.
Remember, however, if that location is not available, OneDrive will not sync.
Alternatively, you can set OneDrive to not store files locally at all. This is done by opening the OneDrive App from Start and going into the settings. You would need to have a network connection in order to access them at that point, but they will take up no space at all on the local drives.