Freshpaint is great but no layers. Autodesk sketchbook is great but you have to pay for features yearly or buy Sketchbook Pro 7 outright. I am trying a new one Mischief that is really interesting
I'm running Presonus Studio 1 on it with absolutely no problems. I use a small Focusrite USB audio device and it makes great portable recording solution. For writing, I added the excellent Literature and Latte's Scrivener.