I use Nod32 anti-virus only, not the suit program. And for IE and testing unsure or trial programs, I use sandboxie to sandbox it.
Few weeks ago, before I got NOD32, I was browsing some random website with IE running in sandboxie, a page popped up with an unclosable window telling me to for me to pay and enter the verification code to unlock the window. I use sandboxie to terminate the sandboxed IE and cleared the sandbox contents, then reopen IE and all is fresh and new. Highly recommended!